心肌肌钙蛋白与马拉松等耐力运动后右心室心肌损伤的综述研究     

张玉丽  王松涛 《中国体育科技》2020,(6):22-31

作为心肌损伤的特异性指标,心肌肌钙蛋白(cTn)在临床诊断心肌病中具有较高的价值。马拉松等耐力运动后,血清cTn异常升高的生理、病理意义仍存在较大争议。通过总结马拉松等耐力运动后cTn的释放规律和右心室(RV)损伤情况,研究探讨了运动后血清cTn的可能来源,以及利用血清cTn评价运动后RV心肌损伤性质的可行性。研究认为:1)一次性马拉松等耐力运动后的血清cTn异常升高,可能是由于RV心肌结构蛋白损伤所致;2)一次性马拉松等耐力运动,可能导致不同性质的RV心肌损伤,通过结合运动后血清cTn的升高水平和持续升高的时间,可以对RV心肌损伤的性质进行评价。  相似文献   

Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study     

Ramesh Chander  Farhan Rizvi  A. K Khanna  Ram Pratap 《Indian journal of clinical biochemistry : IJCB》2003,18(2):71-79

Guggulsterone, a mixture of cis (E) and trans (Z) isomers (7∶3 w/w) was synthesized from 16-DPA. The isomers were separated by column chromatography and evaluated for cardioprotective and antioxidant activities. Myocardial necrosis induced by isoproterenol in rats caused marked increase in serum creatine phosphokinase and glutamate pyruvate transaminase. Simultaneously in ischemic heart, phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen, phospholipids and cholesterol. Treatment with guggulsterone and its both isomers at the dose of 50 mg/kg po., significantly protected cardiac damage as assessed by the reversal of blood and heart biochemical parameters in ischemic rats. The cardioprotective activity of guggulsterone and of both the isomers were compared with that of gemfibrozil at the same doses. Guggulsterone and both the isomers at tested concentrations (5–20mM) inhibited oxidative degradation of lipids in human low-density lipoprotein and rat liver microsomes induced by metal ionsin vitro. The drug counteracted against the generation of superoxide anions (O₂) and hydroxyl radicals (OH⁻) in non-enzymic test systems. It is suggested that cardioprotective and antioxidant activities of synthetic guggulsterone and guggulsterone obtained from gum resinCommiphora mukul that contains isomers E & Z in the ratio of 46∶54w/w are the same.  相似文献   

利用定位UAS-RNAi系统筛选果蝇运动抗心功能増龄衰退候选钙调控基因     

田旭  郑澜  夏晓璇  文登台  陈珏君  奉悦  王卉 《北京体育大学学报》2015,38(2):72-78

目的:研究果蝇心肌细胞Ca2+调控相关基因敲减对増龄果蝇心脏功能及寿命的影响,筛选与心脏功能密切相关的Ca2+调控基因作为候选基因,为研究増龄果蝇基于Ca2+调控基因功能改变的心脏运动适应机制提供依据。方法:Hand-GAL4品系雄蝇、Ca2+调控相关基因UAS-RNAi品系雄蝇与野生型W1118处女蝇杂交,获得基因型为Hand/+和calcium regulation gene RNAi/+的F1代果蝇作为对照组果蝇;HandGAL4品系雄蝇与Ca2+调控相关基因UAS-RNAi品系处女蝇杂交,获得F1代基因型为Hand>calcium regulation gene RNAi的果蝇为心肌组织Ca2+调控基因RNAi组果蝇。采用M-mode方法对1周龄(约为人类青少年时期)和5周龄(约为人类中老年时期)成体果蝇心脏功能衰退相关FS、AI、FL等指标进行检测,并统计各组果蝇存活情况,制作存活曲线。结果:Ca MKII基因心肌敲减果蝇与对照组相比:存活率明显下降,1周龄时表现为FS下降显著,FL明显增高,5周龄时表现为DI,FS明显下降,SI,AI和FL显著上升;5周龄Ca-α1D基因心肌敲减果蝇对比同龄对照组,DI、SI明显降低,DD、SD明显增高;5周龄Anx B9基因敲减果蝇AI较同龄对照组显著上升。结论:Ca MKII基因在维持増龄果蝇心脏功能和寿命中发挥着重要作用,Ca MKII、Ca-α1D和Anx B9可作为候选基因研究増龄果蝇心脏功能运动适应的潜在机制。  相似文献   

Mastery Motivation in Children with Intellectual Disability: Is there Evidence for a Down Syndrome Behavioural Phenotype?     

Linda Gilmore  Monica Cuskelly  Melissa Browning 《International Journal of Disability, Development & Education》2015,62(3):265-275

The main purpose of the current study was to provide empirical evidence to support or refute assumptions of phenotypic deficits in motivation for children with Down syndrome (DS). Children with moderate intellectual disability (MID) associated with etiologies other than DS were recruited in an extension of a previous study that involved children with DS and typically developing children. The participants were 29 children with MID and 33 children with DS who were matched on mental age to 33 typically developing children, aged 3–8 years. Mastery motivation was assessed on task measures of curiosity, preference for challenge and persistence, as well as parental reports. There were no significant group differences on the mastery motivation tasks. Parental ratings of mastery motivation differed, with typically developing children generally being rated more highly than each of the disability groups. The view that motivational deficits are part of the DS behavioural phenotype was not supported.  相似文献   

基于多普勒频谱图的力量项目运动员左室舒张期室壁运动研究     

张戈  李献震  田金凯 《吉林体育学院学报》2016,(1):57-61

通过测定和比较正常人和力量项目运动员在静息和逐级递增负荷运动时，室壁多普勒频谱图上E波和A波峰值速度，研究左室后壁主动松弛和被动充盈功能的变化。结果表明：在静息状态，力量项目组房缩期心房收缩对于左室舒张充盈的贡献小于正常组；在逐级递增负荷中，力量项目组心脏舒张功能的动员表现为同时动用主动舒张储备和左房收缩储备，显示出心脏主动舒张的能力强，左房收缩储备大。  相似文献   

Ⅴ型胶原蛋白ａ1链基因多态性与有氧耐力表型的关联性     

邓潇潇  杨贤罡  李燕春 《北京体育大学学报》2017,40(2):45-50

摘要：目的：通过分析Ⅴ型胶原蛋白ａ1链（COL5A1）基因多态性与60名中国北方汉族女子专业长跑运动员机能指标的关联性，探寻预测有氧耐力表型的分子标记。方法：采用联合测试法测得无氧阈和最大摄氧量相关指标，肺功仪测得肺功相关指标。用PCR-RFLP分析COL5A1基因的rs13946、rs12722多态性。结果：1）rs12722位点：不同基因型运动员之间无氧阈摄氧量、无氧阈摄氧量相对值有显著性差异（P<0.05），TT型运动员显著大于CC和CT型。2）rs13946位点：该位点与有氧耐力表型以及肺功之间无关联（P<0.05）。3）rs13946-rs12722单体型：携带TC单体型运动员的无氧阈摄氧量和无氧阈摄氧量相对值指标均显著高于非TC单体型运动员（P<0.025）。结论：1）COL5A1 rs12722 TT基因型可作为预测中国北方汉族女子长跑运动员无氧阈强度下机体氧耗量的分子遗传学标记。2）TC单体型可作为预测北方汉族女子长跑运动员无氧阈摄氧量及其相对值指标的分子遗传学标记。  相似文献   

心安灵对麻醉犬心肌缺血的保护作用     

阮鸣 《南京晓庄学院学报》2006,22(4):115-117

目的:观察心安灵对冠脉结扎麻醉犬的保护作用.方法:麻醉犬冠脉结扎复制心肌缺血模型.观察给药后ST段偏移总和(Σ-ST)、ST段抬高≥2mv的个数(N-ST)、LDH、CK释放的变化.结果:心安灵可显著减少冠脉结扎所致的Σ-ST抬高和N-ST增加,同时减少血清中LDH和CK的释放.结论:心安灵对麻醉犬冠状动脉结扎所致的心肌缺血具有明显改善作用.  相似文献   

心脏神经症患者的心功能特点     

温晓竞  单迎春  何士麒 《河北北方学院学报(医学版)》2005,22(1):81-82

目的:探讨心脏神经症患者的心功能特点.方法:采用心阻抗法检测46例心脏神经症患者和50例健康成年人的心功能各项指标.结果:心脏神经症患者的SV、CO、CI、HI和AC均明显低于健康对照组(P＜0.01),而TPR明显高于对照组(P＜0.01),而且心脏神经症患者的心室舒张功能显著低于正常对照组.结论:心脏神经症患者的心脏收缩和舒张功能均减退.  相似文献   

A situation-based flipped classroom to improving nursing staff performance in advanced cardiac life support training course     

Bieng-Yi Chang  Ching-Yi Chang  Gwo-Haur Hwang 《Interactive Learning Environments》2019,27(8):1062-1074

ABSTRACT

The Advanced Cardiac Life Support (ACLS) training aims to help nurses establish the basic competence of the comprehension of electrocardiograms (ECG/ EKG). However, learners usually have difficulty memorizing the meanings of different EKG waveforms, which could represent clinical symptoms or even the feeling of dying, via traditional instruction. Some serious problems could lead to death if the nursing staff do not make correct judgments and provide timely treatment. Thus, this paper reports an explorative study investigating the effects of a flipped classroom approach on nursing staffs’ ACLS learning achievement. A 2-week experiment was conducted to compare the learning achievement of the nursing staff who learned with the ACLS situation-based flipped classroom approach to those who learned with the ACLS traditional flipped approach. The experimental results show that the nursing staff who learned with the proposed approach had better learning achievements, motivation, and satisfaction than those who learned with the ACLS traditional flipped approach.  相似文献   

心衰康煎液对阿霉素心衰模型大鼠心肌的影响     

季增荣  金春亭  王淑强  王陶冶 《河北北方学院学报(医学版)》2001,18(6):10-11

目的观察中药复方制剂"心衰康煎液"对心衰大鼠心脏血流动力学的影响及心肌细胞的病理学改变.方法利用pclab实验记录分析系统观察和分析各实验组大鼠左心室内压、对大鼠心肌切片H.E染色镜下观察.结果心衰康使心衰得到明显改善,心肌细胞无明显变性、坏死.结论中药复方"心衰康煎液"对心衰大鼠的心肌病变有明显改善,从而产生良好的抗心衰作用.结论  相似文献